Journal of Medical and Surgical Intensive Care Medicine 2017 , Vol 8, Issue 1
A Case of Fulminant Wilson's Disease Complicated with Citrate Toxicity
Mey Talip Petmezci 1 , Hasan Serdar Kıhtır 1 , Osman Yeşilbaş 1 , Seda Balkaya 1 , Esra Şevketoğlu 1 , Elida Yüksel 2 , Zerrin Önal 2
1Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Çocuk Yoğun Bakım Ünitesi, İstanbul, Türkiye
2Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği, İstanbul, Türkiye
DOI : 10.5152/dcbybd.2016.1138

When Wilson’s disease is accompanied with severe acute liver failure, it is named as  fulminant Wilson’s disease, which is a life-threatening condition. With the widespread use of rapid diagnostic facilities and therapeutic plasma exchange in preparation of transplantation as well as the correct use of similar bridge treatments, mortality rate can be lowered. A 14-year-old female patient presented with hemolytic anemia. Based on the preliminary diagnosis, her indirect hyperbilirubinemia was treated with plasmapheresis until she was definitely diagnosed with Wilson’s disease; she soon died due to severe hemorrhagic complications. We are presenting our case to highlight that bridge therapies may be unsuccessful because of rapidly developing clinical manifestations despite plasmapheresis;and as well to remind, transfusions may cause citrate toxicity as in this patient.

Cite this article as: Pekmezci MT, Kıhtır HS, Yeşilbaş O, et al. Case of Fulminant Wilso's Disease Complicated with Citrate Toxicity.  Yoğun Bakım Derg 2017; 8: 25-7.

Keywords : Wilson’s disease, acute liver failure, plasma exchange, hemolytic anemia