Journal of Critical and Intensive Care Online Early
The Relationship Between Hypoalbuminemia and Mortality in Geriatric Patients with Sepsis
Murat ERDOGAN 1 ,Huseyin Avni FINDIKLI 2
1University of Health Sciences - Adana Health Practice and Research Center, Crtical Care Medicine, Adana, Turkey
2Necip Fazıl City Hospital, General Internal Medicine, Kahrmanmaraş, Turkey
DOI : 10.37678/dcybd.2021.2824 Aim: Albumin can be used as prognostic markers for various clinical results including critical care patients. In our study, we aimed to examine the relationship between albumin and mortality in geriatric patients with sepsis.

Design: Retrospective Study

Materials and Methods: This study included geriatric patients with sepsis treated in the medical intensive care unit of Adana City Training and Research Hospital between January 2018 and December 2020. Two hundred and fifty-two patients were enrolled in the study.

Results: The median acute physiology and chronic health evaluation II (APACHE II), sequential organ failure assessment, and Charlson Comorbidity Index score were significantly higher in the non-survivors group. According to the laboratory parameters the serum levels of creatinine and, C-reactive protein were significantly higher in the non-survivor group. The serum level of platelets and albumin was significantly higher in the survivor group. In the multivariate analysis, age, APACHE II, platelets, and albumin were determined as significant independent determinants after the correction of the other variables. The lower albumin levels were associated with an increased risk of mortality in geriatric patients with sepsis. In the receiver operating characteristic curve analysis, albumin values of 2.85 and below were predictive for mortality.

Conclusion: Albumin levels can be used as a predictor of mortality in geriatric patients with sepsis. In addition, studies should be planned to evaluate whether the APACHE-2 score and albumin level together can better predict mortality in geriatric patients with sepsis. Keywords : geriatrics, intensive care unit, mortality, sepsis