Journal of Medical and Surgical Intensive Care Medicine 2014 , Vol 5, Issue 1
What Has Changed in Sepsis Management?
Gülseren Elay 1 , Kürşat Gündoğan 1 , Ramazan Coşkun 1
1Erciyes Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Yoğun Bakım Bilim Dalı, Kayseri, Türkiye DOI : 10.5152/dcbybd.2014.579

The most important reasons of mortality and morbidity in the intensive care unit are severe sepsis and septic shock. It is estimated that more than 200,000 patients in the USA and more than 150,000 patients in Europe die with a diagnosis of severe sepsis every year. In sepsis, an excessive and irregular response of hosts is available against infection. Multiorgan failure and hypovolemic shock may occur if the patient is not treated. Multiorgan failure is the most common cause of death in sepsis. It has been observed that application of the protocols in sepsis guides reduces mortality. The American College of Chest Physicians and Society of Critical Care Medicine organized a meeting in order to create a standard definition of sepsis syndromes in 1991, and sepsis syndromes were  defined in the manual (guide), which was published in 1992. In order to improve the results of the treatment of severe sepsis and septic shock, international guidelines were published in 2004 and then in 2008 by a group of experts in the diagnosis and treatment of sepsis. In the last manual, which was published 2012, there has been some additions and changes. Compared to the 2008 guidelines, the severe sepsis and septic shock guidelines that were published by the Surviving Sepsis Campaign in 2012 are summarized below, along with the quality of evidence and recommendations. 

Keywords : Severe sepsis, septic shock, intensive care