ACTA Pharmaceutica Sciencia 2010 , Vol 52 , Num 3
OPTIMIZATION OF MATRIX DIFFUSION MEDIATED TRANSDERMAL THERAPEUTIC SYSTEM FOR BUSPIRONE: EFFECT OF VARIABLES ON IN VITRO RELEASE, EX VIVO PERMEATION AND PHARMACOTECHNICAL PROPERTIES
RAMESH GANNU, PRADEEP KUMAR VUPPALA, SHRAVAN KUMAR MADİSHETTY, SHİVA KUMAR RAVULA, PAVAN KUMAR P, MADHUSUDAN RAO YAMSANİ
National Facilities in Engineering and Technology with Industrial Collaboration (NAFETIC) Centre, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009, Andhra Pradesh, India The purpose of present study was to develop and optimize matrix type transdermal patches for buspirone, a low bioavailable drug. Transdermal patches were optimized using a three-factor, three- level Box-Behnken design, the independent variables selected were d-limonene, transcutol and propylene glycol; dependent variables (responses) were cumulative amount released in 24 h (Q24R; Y1), flux (Y2), and tensile strength (Y3). Mathematical equations and response surface plots were used to relate the dependent and independent variables. All formulations followed zero order release kinetics and the release pattern was found to follow non-fickian model. The regression equations were generated for responses Y1, Y2 and Y3. The statistical validity of the polynomials was established, and optimized formulation factors were selected by feasibility and grid search. Validation of the optimization study with 7 confirmatory runs indicated high degree of prognostic ability of response surface methodology. The optimized formulation (B-OPT) showed a flux of 92.5 >g cm-2 h-1, which could meet target flux. Matrix diffusion mediated transdermal patches having suitable mechanical properties for BUSP were developed and optimized using Box-Behnken statistical design. Keywords : MATRIX TYPE TDDS, BUSPIRONE, BOX-BEHNKEN, OPTIMIZATION, MECHANICAL PROPERTIES, TENSILE STRENGTH

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