Journal of Critical and Intensive Care Online Early
Use of an Automated Ventilation Mode in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial
Burcu ACAR CINLETI 1 ,Tunzala YAVUZ 2 ,Huseyin OZKARAKAS 3 ,Ilknur NAZ 4 ,Suleyman YILDIRIM 5 ,Cenk KIRAKLI 5
1Izmir Democracy University Buca Seyfi Demirsoy Training and Research Hospital, Faculty of Medicine,Department of Neurology, Intensive Care Unit, İzmir, Türkiy
2University of Health Sciences Turkey, Izmir School of Medicine, Izmir Tepecik Training and Research Hospital, Intensive Care Unit, İzmir, Türkiye
3University of Health Sciences Turkey, Izmir School of Medicine, İzmir Bozyaka Training and Research Hospital, Intensive Care Unit, İzmir, Türkiye
4Izmir Katip Celebi University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, İzmir, Türkiye
5University of Health Sciences Turkey, Izmir School of Medicine, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, Intensive Care Unit, İzmir, Türkiye
DOI : 10.37678/dcybd.2024.3638 Background/aim: Prolonged mechanical ventilation is a clinical condition that leads to higher complication rates and a longer stay in the intensive care unit. Shortening the duration of mechanical ventilation is one of the main goals of intensive care. In this study we aim to evaluate a fully closed loop mode, INTELLiVENT®- ASV®, in ventilating chronic obstructive pulmonary disease (COPD) patients in terms of ventilation duration and workload of clinicians when compared with a conventional mode.

Methods: COPD patients who followed up in invasive mechanic ventilation (IMV) were randomized into INTELLiVENT®-ASV® or P-ACV. Ventilation data were recorded with a dedicated software connected to the ventilator. Duration of mechanical ventilation and weaning, number of manual and automatic settings of the ventilator and other clinical endpoints were compared between the two groups.

Results: IMV duration was found to be lower in the INTELLiVENT®-ASV® group [1.9 (1.0-3.8) vs. 3.0 (1.9- 5.2) days, p=0.02]. The number of manual changes to ventilator settings and arterial blood gas analyses per day were significantly lower in the INTELLiVENT®-ASV® group than in the P-ACV group [1.2 (0.2-1.7) vs. 6.8 (4.6-8.2), p<0.001 and 1.38 (1.03-2.06) vs. 2.09 (1.58-7.74), p <0.05 respectively].

Conclusion: The use of closed-loop mechanical ventilation may reduce IMV duration and the workload of clinicians and respiratory therapists. Keywords : COPD, mechanical ventilation, prolonged mechanical ventilation, closed-loop ventilation, weaning