ACTA Pharmaceutica Sciencia 2005 , Vol 47 , Num 2
EFFECT OF ARQ GAUZABAN A UNANIPATHY PRODUCT ON THE ISOLATED FROG HEART
BHEEMACHARİ J, ASHOK K, SURESH D K, GUPTA V R M, NARSİMHACHAR J
Department of Pharmacology and Department of Pharmacognosy, N.E.T Pharmacy College, Mantralayam Road, Raichur, India Arq gauzaban (a clear aqueous distillate of the plant Onosma bracteatum) a unanipathy product recommended by the unanipathy practioners to strengthen the sick heart both pre and post operatively was studied. Despite its extensive use in unanipathy health care system, no systematic study has been reported so far. Hence, in the present study an effort was made to screen the product for its cardiac effects on isolated frog heart. Arq guazaban exhibited a positive inotropic effect on the isolated perfused frog heart. The main mechanism behind this pharmacological response appears to be through the calcium channels. The study thus further supports the use of arq guazaban as a myocardial strengthening agent in unanipathy health care practice. Keywords : ARQ GAUZABAN, POSITIVE INOTROPIC EFFECT, BETA BLOCKER, CALCIUM CHANNEL BLOCKER, ISOLATED FROG HEART

Istanbul Medipol University