ACTA Pharmaceutica Sciencia 2009 , Vol 51 , Num 3
EVALUATION OF PRESERVATIVE EFFECTIVENESS IN AN OFFICIAL ANTACID PREPARATION
The effective antimicrobial anilide derivatives from our earlier study were subjected to preservative efficacy testing in an official antacid preparation, (Aluminium Hydroxide Gel-USP) against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans and Aspergillus niger as representative challenging microorganisms as per USP guidelines. The selected anilide derivatives were found to be effective against C. albicans, E. coli and S. aureus and showed preservative efficacy comparable to that of standard and even better in case A. niger. This study showed the potential of anilides to be used as a preservative in pharmaceutical products. Keywords : ANILIDES, PRESERVATIVE, LOG CFU/ML

Istanbul Medipol University