ACTA Pharmaceutica Sciencia 2008 , Vol 50 , Num 3
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL ANALOGUE OF P-HYDROXYANILINE
RAMESH KUMAR, SANDEEP JAIN, NEELAM JAIN, MONIKA SINGH
Lord Shiva College of Pharmacy, Sirsa-125055, Haryana In the present study, eight new derivatives (R1 to R8) of p-hydroxyaniline were synthesized to investigate their analgesic, antipyretic and anti-inflammatory activities. p-Hydroxyaniline on reaction with appropriate dicarboxylic acid chloride (oxalyl chloride, malonyl chloride, succinyl chloride and glutaryl chloride) yielded four compounds (R1 to R4). Compounds R5 and R6 were synthesized by reacting p-hydroxyaniline with acid anhydride (succinic anhydride and glutaric anhydride). Cyclization of these compounds (R5 and R6) yielded compounds R7 and R 8, respectively. All the synthesized compounds were identified by IR, NMR and elemental analysis and spectral data of. The analgesic, antipyretic and anti-inflammatory activity were investigated in-vivo and appreciable activity were observed. Keywords : P- HYDROXYANILINE, ANALGESIC, ANTIPYRETIC, ANTI-INFLAMMATORY

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